Depression Can Hamper Glucose Control in People with Diabetes

Depression can cause diabetes patients to suffer from higher glucose levels over time compared to those who are not depressed, finds a study of older veterans with the disease.

“Our study shows that depression is a major and important comorbidity in people with type 2 diabetes,” study co-author Leonard Egede, MD, from the Center for Health Disparities Research at the Medical University of South Carolina, said in a news release.

Through a combination of diet, exercise and medication, people with type 2 diabetes work to keep their blood glucose levels within a certain range. Past research has shown that those who are also depressed have a tougher time doing so. About 30% of adults with diabetes have depression and the combination is linked to poor glucose control, higher complication rates, decreased quality of life and increased risk of death.

Egede and his colleagues analyzed data from 11,525 veterans (98% men) with type 2 diabetes who received medical care at a Veterans Administration facility in the Southeast. The participants’ average age was 66 years and 48% were white, 27% were African-American and 25% were of other races.

Researchers evaluated each participant at 3-month intervals from 1997 to 2006, with 36 intervals. At each 3-month interval, clinicians checked their HbA1c level, a blood test that measures long-term glucose control. Experts recommend a target level of less than 7%.

Six percent of the participants had depression, researchers determined.

They found that over the 4-year period, the HbA1c values in the veterans who were depressed averaged 0.13% higher than the veterans who were not depressed. Egede said the difference is quite significant — enough to raise people with diabetes above the desirable range for glucose control, putting them at higher risk.

“The fact that the difference persisted over time and that the depressed group had higher mean HbA1c at all 36 time points was surprising,” Egede said.

The researchers also found that the change in HbA1c among the depressed participants did not differ based on race or age.

Evette Joy Ludman, PhD, senior research associate at the Group Health Center for Health Studies in Seattle, said that although the link between depression and diabetes complications might seem daunting, it is possible for adults to follow treatment orders for their depression while also managing their diabetes.

“I think it is a reasonable expectation that health care teams can help patients who have both depression and diabetes manage both conditions,” she said. “I don’t think patients see themselves as a collection of different illnesses and if we take a more proactive, integrated approach to caring for them, it is likely they can benefit. Research currently in the field is addressing that exact question.”

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