Both baseline levels of daily ambulatory activity and change in ambulatory activity were inversely associated with the subsequent risk of cardiovascular event in individuals at high cardiovascular risk with impaired glucose tolerance, according to a study published in The Lancet.
Researchers assessed prospective data from the NAVIGATOR trial involving 9,306 individuals with impaired glucose tolerance, as well as existing cardiovascular disease or at least one additional cardiovascular risk factor. For an average of 6 years, researchers followed up with participants for cardiovascular events and assessed ambulatory activity with a pedometer at baseline and 12 months. After adjustment for potential confounding variables, researchers used adjusted Cox proportional hazard models to determine the association of baseline and change in ambulatory activity with the risk of subsequent cardiovascular event.
Study results showed baseline ambulatory activity and change in ambulatory activity were inversely associated with risk of a cardiovascular event. When researchers adjusted for changes in body mass index and other potential confounding variables at 12 months, they found results for change in ambulatory activity were also unaffected.
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Disclosure: The research was funded by Novartis Pharmaceuticals.