Olfactory receptor in skin accelerates wound healing, skin regeneration

Data published in the Journal of Investigative Dermatology by researchers at the Ruhr-Universität Bochum found an increase in cell proliferation and improvement in wound healing if certain olfactory receptors in the skin are activated.

Researchers cloned and functionally expressed the cutaneous olfactory receptor OR2AT4 and found a synthetic sandalwood odorant, known as Sandalore, as an agonist of the receptor. When activated, OR2AT4 triggers a calcium-dependent signal pathway which ensures an increased proliferation and a quicker migration of skin cells.

“These findings combined with our studies on human skin organ cultures strongly indicate that the olfactory receptor 2AT4 is involved in human keratinocyte reepithelialization during wound healing processes,” the researchers wrote.

For more information:

Busse D. J Invest Dermatol. 2014;doi:10.1038/jid.2014.273.

Disclosures: The researchers have no relevant financial disclosures.

Leave a Reply

Your email address will not be published.