Study: Lower limb deficiency creates high risk for major nonlimb anomalies

In a study of patients with lower limb deficiency, 47.7% also had other major anomalies, according to research published in The Journal of Bone & Joint Surgery. The risk for associated major anomalies was highest in patients with preaxial lower limb deficiencies. 

Researchers led by Johanna Syvänen, MD, examined 266 cases of lower limb deficiency using data from the Finnish Register of Congenital Malformations and Care Register for Health Care. All cases of lower limb deficiency from 1993 to 2008 were included. Of these, terminal transverse limb reductions accounted for 44.7% of cases; longitudinal reductions, 22.9%; intercalary reductions, 7.9%; multiple reductions, 8.3%; and split-foot malformations, 4.5%.

Of the 47.7% of people with additional major anomalies, 26.3% had anomalies of internal organs; 13.5% had anomalies of the axial skeleton; and 12.8% had anomalies of the central nervous system. Additionally, 32% of patients also had upper limb reductions.

For more information:

Syvänen J. J Bone Joint Surg Am, 2014; doi:10.21.106/JBJS.N.00155.

Disclosure: One or more of the authors received payments or services, either directly or indirectly, from a third party in support of an aspect of this work. In addition, one or more of the authors, or his or her institution, has had a financial relationship in the 36 months prior to submission of this work, with an entity in the biomedical arena that could be perceived to influence or have potential to influence what is written in this work. See the study for a full list of all authors’ relevant financial disclosures.

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