Long-Term Use of Osteoporosis Drugs Linked to Unusual Fractures, Study Finds

Women who take commonly prescribed drugs, known as bisphosphonates, for osteoporosis for 5 years or more may be at higher risk of certain kinds of fractures of their thigh bones, a new study has found.

The drugs do prevent hip fractures, however, and, since the overall risk of thigh bone fractures caused by the drugs is low, women at high risk for hip and other osteoporosis-related fractures should not stop taking bisphosphonates, according to researchers at St. Michael’s Hospital and the Institute for Clinical Evaluative Sciences.

The study was published in the Journal of the American Medical Association.

“Prolonged use of bisphosphonates is associated with rare and unusual fractures of the femur,” Laura Park-Wyllie, lead author of the study and a pharmaceutical safety and outcomes researcher at St. Michael’s, stated in a press release. “But the proven benefit of these drugs for the much more common fractures of osteoporosis usually outweighs the harm, especially in the initial years of treatment for osteoporosis. Women with osteoporosis, at high risk for osteoporotic fractures, should not stop taking bisphosphonate therapy because of the small risk of these thigh fractures.”

Typical hip fractures caused by osteoporosis occur in the upper part of the femur close to the hip joint and are an important cause of disability, need for long-term care and even death in the elderly. The risk of these kinds of fractures is reduced by bisphosphonate treatment, which was confirmed by this study.

The study found that less common fractures lower down from the hip and closer to the middle of the femur — sometimes called “atypical” or “unusual” fractures — occurred more than 2.5 times as often in women who had taken bisphosphonates for more than 5 years longer than short-term users of the drug.

The St. Michael’s-ICES study is the largest assessment of the issue to date. The researchers identified 205,466 women older than the age of 68 years who had been prescribed bisphosphonates between 2002 and 2008.

Of those, 716 women, 0.35%, had a fracture of the femur. These women were compared to other women of similar ages who had also been prescribed the drugs but who did not have femur fractures.

“Our study estimated that the risk of fractures to the femur was 0.13% for women entering their sixth year on the drug — or just over one in 1,000,” Park-Wyllie stated. “Use of bisphosphonates for less than 5 years was not associated with a significant risk of thigh fractures.”

About 50% of women older than 50 years will suffer an osteoporosis-related fracture. The most common involve the wrist and the spine, but hip fractures can have some of the most severe consequences, with one in five of those women expected to die within 12 months.

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