Spine Surgery Patients Have Low Vitamin D Levels, Study Finds

A new study indicates that many patients undergoing spine surgery have low levels of vitamin D, which may delay their recovery. Orthopaedic surgeons at Washington University School of Medicine in St. Louis found that more than half of the 313 patients undergoing spinal fusion surgery had inadequate levels of vitamin D, including one-fourth who were more severely deficient.

The researchers reported their findings at the 26th Annual Meeting of the North American Spine Society.

“Our findings suggest it may be worthwhile to screen surgery patients for vitamin D,” Jacob M. Buchowski, MD, the study’s principal investigator, stated in a press release. “We think those with insufficient levels of vitamin D may benefit from taking 50,000 international units of the vitamin once a week for 8 weeks before surgery as this may help the recovery after spinal fusion surgery.”

Vitamin D helps with calcium absorption, and patients with a deficiency can have difficulty producing new bone. They are at risk for a condition called osteomalacia. Unlike osteoporosis or osteopenia, which result from low bone mineral density, osteomalacia interferes with new bone formation.

All the patients in the study had spinal fusion surgery. In that procedure, surgeons remove discs between two or more vertebrae. The bones in the spine are then attached with hardware and treated with growth factors. As the spine heals, new bone begins to form, and the vertebrae fuse together.

Buchowski became aware of the vitamin D problem when a patient in her 40s experienced a slow recovery after the surgery.

“I was examining her and trying to figure out why the vertebrae didn’t fuse,” he said. “She mentioned that she had recently been diagnosed with vitamin D deficiency, and it was like a light bulb went off.”

As a result, Buchowski, an associate professor of orthopaedic surgery and of neurological surgery, and his Washington University colleagues at Barnes-Jewish Hospital, started routinely screening spinal fusion surgery patients for vitamin D deficiency. Low vitamin D levels are common in elderly patients. However, in this study, the patients most likely to have inadequate levels of the bone-building vitamin were younger.

“We rarely think about deficiency in younger patients,” Buchowski said. “More of the older patients in this study had a history of taking supplements, and as a result, they had less risk for vitamin D deficiency than younger patients.”

Those in the study averaged 55 years of age, 56% were female, 41% were obese, and 95% were white. One quarter of the participants had taken vitamin D supplements in the past. The researchers found that the main risk factors for inadequate vitamin D were smoking, obesity, disability prior to surgery and never having taken vitamin D or multivitamin supplements.

Buchowski now recommends that patients having orthopedic surgery ensure they’re getting enough vitamin D.

Sun exposure is one of the best ways to get the body to produce vitamin D. Patients may also consume dairy products fortified with the vitamin and begin taking a vitamin D supplement prior to and following surgery.

“Vitamin D is inexpensive and easily stored in the body,” Buchowski said. “My hunch is that having adequate levels may help the spine fuse following surgery.”

To maintain bone health and normal calcium metabolism, the Institute of Medicine established a recommended daily allowance (RDA) for vitamin D of 600 international units. Buchowski says patients should work with their doctors to determine what supplemental level is appropriate for them.

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